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River Cruises in South America

The river shows you what the roads miss.

The Amazon basin, the Andes, Patagonia, the Galapagos, and the cosmopolitan cities of São Paulo, Buenos Aires, and Bogotá. South America is the OS's primary region for global-expedition-adventures and global-hiking-tours, anchored by Peru, Patagonia, and Ecuador.

12 countries
Hub: GRU
1 destination in this region
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Pick your providers for River Cruises in South America

Three simple groups — Aggregators to search & compare, Major Global names, and Regional specialists. Six at a time, so you never wade through a wall of logos.

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Top destinations in South America

Expert guides for River Cruises travel — each with provider recommendations, a safety card, and the full 10-Well coverage. Showing the top 12, six at a time.

Best Time to Visit South America

Peak Season

June–September (Southern Hemisphere winter — best for Patagonia)

Shoulder Season

March–May, October–November

Low Season

December–February (Patagonian summer — crowded)

Peak season varies dramatically by destination within this large region.